Nitric Oxide (NO): Definition and Physiological Role
Nitric oxide (NO) is a gaseous molecule naturally produced by the body. It acts as a key cellular messenger, particularly within the cardiovascular system, where it contributes to the normal function of the endothelium (the inner lining of blood vessels). NO is known for its role in relaxing vascular smooth muscle, a mechanism involved in physiological vasodilation (widening of blood vessels).
In simple terms: when NO is released locally, it sends a signal to blood vessels to promote relaxation. This physiological response is associated with improved delivery of oxygen and nutrients, which explains the interest in NO for vitality, circulatory well-being, and exercise performance.
How Does the Body Produce Nitric Oxide?
The body relies on two major complementary pathways:
1) Enzymatic Pathway (L-arginine → NO)
NO is synthesized from L-arginine through enzymes called nitric oxide synthases (NOS), especially endothelial NOS (eNOS). This pathway depends on several cofactors and on the cellular oxidative balance.
2) Dietary Pathway (nitrates → nitrites → NO)
This widely studied pathway begins with dietary nitrates (NO₃⁻) obtained from food sources (e.g., beetroot). Nitrates are partially converted into nitrites (NO₂⁻) by bacteria in the mouth, then into NO within the body.
This pathway is considered a physiological reservoir of NO, particularly relevant when the body's needs increase (e.g., during physical activity).
Mechanism of Action
Once produced, NO rapidly diffuses toward vascular smooth muscle cells, where it activates an enzyme called soluble guanylate cyclase (sGC).
This activation increases levels of cGMP (cyclic guanosine monophosphate), a secondary intracellular messenger involved in smooth muscle relaxation.
Result: the vessel wall relaxes, contributing to physiological vasodilation and optimized blood flow as part of the body's normal functions.
Why Support NO Bioavailability?
NO production and availability may be influenced by several factors: age, lifestyle, oxidative stress, sedentary habits, and dietary quality.
From a “well-being” perspective, supporting NO pathways is sought in order to:
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support optimal blood circulation (physiological function)
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promote a feeling of endurance and performance
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support overall vitality and improved exercise quality
Important: these statements remain within the scope of well-being and normal physiological functions, in accordance with European requirements.
Why Combine Nitrates + Polyphenols + CoQ10?
Beetroot (nitrates): supporting the nitrates → NO pathway
Beetroot extracts are well known for their nitrate content. Nitrates increase the availability of plasma nitrites, a marker often used to reflect the activity of the nitrate → NO pathway. Several studies and scientific reviews have highlighted the interest of this pathway in the context of exercise and vascular function.
Grape seed extract (polyphenols): supporting oxidative balance
NO can be “captured” by certain reactive oxygen species (oxidative stress), which reduces its bioavailability. Polyphenols (such as those from grape seed) are studied for their antioxidant properties and their role in oxidative balance, supporting a global approach to NO support.
Coenzyme Q10: cellular energy and oxidative protection
CoQ10 is an important cofactor in the mitochondrial respiratory chain, associated with energy production. It is also studied for its role in oxidative balance. In a complex formula, it supports the “vitality / performance” approach.
Nitric-Ox is a complex designed to support the body’s natural production of nitric oxide and promote optimal circulation.
Its formula combines a beetroot-based nitrate support blend (including an extract standardized to 10% nitrates in the form of NO3-T®), grape seed extract, and coenzyme Q10.
Nitric-OX is ideal as part of a vitality routine or before physical activity. It is designed for individuals seeking improved feelings of endurance, energy, and daily performance.
How does Nitric-OX work?
Nitric-OX relies on the nitrate → nitrite → nitric oxide (NO) pathway, a well-documented physiological mechanism.
Dietary nitrates (especially those from beetroot) can be converted into nitrites and then into nitric oxide in the body, helping to support NO production.
Why choose Nitric-OX?
Key benefits
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A formula dedicated to nitric oxide (NO) support
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Beetroot + standardized nitrate extract NO3-T®
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Synergy of polyphenols (grape seed extract) + CoQ10
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Ideal as part of a daily vitality routine or before exercise
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Designed to support optimal circulation and a feeling of endurance
Who is Nitric-OX for?
Nitric-OX may be suitable for anyone looking to support circulation and vitality, especially:
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Athletes (endurance and sensations during exercise)
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Active individuals looking to support daily energy
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People seeking circulatory comfort as part of a wellness routine
How to use Nitric-OX?
Directions for use
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2 capsules per day, preferably with a meal.
Recommendations
For optimal use, it is recommended to include it in a regular routine, alongside a varied and balanced diet and a healthy lifestyle.
Results: What to expect
Nitric oxide is associated with the physiological response of normal vasodilation.
In a wellness approach, Nitric-OX is used to support:
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a feeling of optimal circulation
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endurance
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energy and vitality
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a feeling of performance
(Results may vary from one person to another. This product is not a medicine.)
FAQ – Frequently Asked Questions about nitric oxide and Nitric-OX
What exactly is Nitric-OX?
Nitric-OX is a food supplement designed to support the body’s natural production of nitric oxide through a formula based on beetroot (nitrates), grape seed extract, and CoQ10.
Why is beetroot used for nitric oxide?
Beetroot is naturally rich in nitrates, which can be converted into nitrites and then into nitric oxide in the body through a widely studied physiological pathway.
Can Nitric-OX be taken every day?
The label recommends 2 capsules per day.
If you are taking medication, please consult a healthcare professional before use.
How long does it take to feel the effects?
This varies depending on individual sensitivity, lifestyle, and regularity of use. Some people take it daily as part of a routine, while others use it more occasionally before exercise.
Is Nitric-OX suitable for athletes?
Yes. It is commonly used as part of an endurance and exercise performance routine, supporting circulation and energy.
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Do not exceed the recommended daily dose.
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Keep out of reach of children.
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Not recommended for pregnant or breastfeeding women, individuals under 18, or people under medical treatment or with a medical condition without medical advice.
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Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle.
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This product is not intended to diagnose, treat, cure, or prevent any disease.
Scientific Sources (Major References)
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Furchgott RF & Zawadzki JV (1980) – role of the endothelium in vascular relaxation, Nature.
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Palmer RMJ, Ferrige AG & Moncada S (1987) – identification of NO as EDRF, Nature.
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Lundberg JO, Weitzberg E & Gladwin MT (2008/2009) – nitrates → nitrites → NO pathway, major reviews (Nature Reviews / scientific reviews).
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Jones AM (2014) – dietary nitrates and exercise performance, Sports Medicine.
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Hobbs DA et al. (2013–2015) – nitrates, nitrites and vascular physiological parameters, American Journal of Clinical Nutrition and related reviews.